Scientists from the CRCM and the IPC, in collaboration with Institut Curie, have just demonstrated that cancer cells use a membrane protein which has been described several decades ago and internalizes iron. Published in Nature Chemistry on August 3, 2020, this work shows that the iron thus absorbed allows cancer cells to acquire the properties of metastatic cells.
CD44 regulates epigenetic plasticity by mediating iron endocytosis. Sebastian Müller, Fabien Sindikubwabo, Tatiana Cañeque, Anne Lafon, Antoine Versini, Bérangère Lombard, Damarys Loew, Ting-Di Wu, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Adeline Durand, Céline Vallot, Sylvain Baulande, Nicolas Servant, Raphaël Rodriguez. Nature Chemistry, le 3 août 2020. DOI:10.1038/s41557-020-0513-5