Sensitive and easy screening for circulating tumor cells by flow cytometry.
Lopresti A, Malergue F, Bertucci F, Liberatoscioli ML, Garnier S, DaCosta Q, Finetti P, Gilabert M, Raoul JL, Birnbaum D, Acquaviva C, Mamessier E
Biography I obtained my PhD at Montpellier University working on the proteolytic regulation of Fos transcription factors in Dr. Marc Piechaczyk’s laboratory at the Institute of Molecular Genetics of Montpellier (IGMM). I next worked as a post-doc in Jonathon Pines’ laboratory at the Gurdon Institute in Cambridge (UK) on the regulation of the cell cycle by proteolysis. I returned to France in Marseille to work on the centrosome, primary cilia, cell cycle regulation and associated pathologies in Dr. Daniel Birnbaum’s laboratory at the CRCM. Since 2016 I investingate the biology of Circulating Tumor Cells (CTCs) and their contribution to cancer metastases. Our main research interest is focused on breast and colon cancers and aim at better defining CTCs at high risk of seeding metastases. For this, we combine innovative technologies (single cells isolation, microfluidic …) with complex organoids generation, either as a source (tumoroid) or a receptacle (multicellular organoid) for CTCs.
Publications
Mutation of FOP/FGFR1OP in mice recapitulates human short rib-polydactyly ciliopathy.
Cabaud O, Roubin R, Comte A, Bascunana V, Sergé A, Sedjaï F, Birnbaum D, Rosnet O, Acquaviva C
Lactate Detection in Tumor Cell Cultures Using Organic Transistor Circuits.
Braendlein M, Pappa AM, Ferro M, Lopresti A, Acquaviva C, Mamessier E, Malliaras GG, Owens RM