Paulo de Sepulveda

Team Leader

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Team

Signaling, Hematopoiesis and Mechanism of Oncogenesis

Dec 2012 Blood

In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells.

Soucie E, Hanssens K, Mercher T, Georgin-Lavialle S, Damaj G, Livideanu C, Chandesris MO, Acin Y, Létard S, de Sepulveda P, Hermine O, Bernard OA, Dubreuil P

May 2014 Haematologica

SRSF2-p95 hotspot mutation is highly associated with advanced forms of mastocytosis and mutations in epigenetic regulator genes.

Hanssens K, Brenet F, Agopian J, Georgin-Lavialle S, Damaj G, Cabaret L, Chandesris MO, de Sepulveda P, Hermine O, Dubreuil P, Soucie E

Nov 2017 Nature communications

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.

Hammam K, Saez-Ayala M, Rebuffet E, Gros L, Lopez S, Hajem B, Humbert M, Baudelet E, Audebert S, Betzi S, Lugari A, Combes S, Letard S, Casteran N, Mansfield C, Moussy A, De Sepulveda P, Morelli X, Dubreuil P

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