The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .
Han H, Yang Y, Olesen SH, Becker A, Betzi S, Schönbrunn E
Biography I joined the iSCB group in January 2011 after a two years postdoc position in the Moffitt Cancer Center (Tampa, Florida) in Ernst Schönbrunn laboratory. My project aims at developing protein-protein interaction inhibitors (PPIs) for protein targets related to cancer. My research focuses on biochemistry, structural biology, medicinal chemistry and molecular modelling.
Publications
4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.
Calbert ML, Chandramouly G, Adams CM, Saez-Ayala M, Kent T, Tyagi M, Ayyadevara VSSA, Wang Y, Krais JJ, Gordon J, Atkins J, Toma MM, Betzi S, Boghossian AS, Rees MG, Ronan MM, Roth JA, Goldman AR, Gorman N, Mitra R, Childers WE, Graña X, Skorski T, Johnson N, Hurtz C, Morelli X, Eischen CM, Pomerantz RT
PDZome-wide and structural characterization of the PDZ-binding motif of VANGL2.
Montserrat-Gomez M, Gogl G, Carrasco K, Betzi S, Durbesson F, Cousido-Siah A, Kostmann C, Essig DJ, Strømgaard K, Østergaard S, Morelli X, Trave G, Vincentelli R, Bailly E, Borg JP