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Jan 2015 Vascular cell

γ-Actin plays a key role in endothelial cell motility and neovessel maintenance.


Pasquier E, Tuset MP, Sinnappan S, Carnell M, Macmillan A, Kavallaris M


Angiogenesis plays a crucial role in development, wound healing as well as tumour growth and metastasis. Although the general implication of the cytoskeleton in angiogenesis has been partially unravelled, little is known about the specific role of actin isoforms in this process. Herein, we aimed at deciphering the function of γ-actin in angiogenesis.

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