Caulerpenyne-colchicine hybrid: synthesis and biological evaluation.
Authors
Bourdron J, Commeiras L, Barbier P, Bourgarel-Rey V, Pasquier E, Vanthuyne N, Hubaud JC, Peyrot V, Parrain JL
Summary
The synthesis of an analog of caulerpenyne having a trimethoxyaryl moiety was achieved in 11% overall yield over 11 steps. Its biological activity has been evaluated as inhibitor of in vitro tubulin polymerization or angiogenesis.
Read the article