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Jan 2015 Cancer informatics

Prediction of early breast cancer metastasis from DNA microarray data using high-dimensional cox regression models.

Authors

Zemmour C, Bertucci F, Finetti P, Chetrit B, Birnbaum D, Filleron T, Boher JM

Summary

DNA microarray studies identified gene expression signatures predictive of metastatic relapse in early breast cancer. Standard feature selection procedures applied to reduce the set of predictive genes did not take into account the correlation between genes. In this paper, we studied the performances of three high-dimensional regression methods – CoxBoost, LASSO (Least Absolute Shrinkage and Selection Operator), and Elastic net – to identify prognostic signatures in patients with early breast cancer.

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