En direct

Le Centre de Recherche en Cancérologie de Marseille fête ses 50 ans ! -

Salle de Conférence IPC2
4 Oct 22 11:00 au 4 Oct 22 12:30

Keynote Dr Stephen West

DNA strand break repair and links to human disease

Keynote Seminar Series

Tuesday October 4th 2022
11h00 am, IPC2 Conference Room

Hosted by the CRCM Genome Stability Department



DNA instability is a major cause of inheritable human diseases, such as cancers or neurological disorders, and is also responsible for many aspects of the ageing process. Fortunately, our cells possess a large repertoire of DNA repair processes that maintain our DNA in perfect condition.

Steve West’s laboratory has pioneered the study of enzymes that promote the intricate DNA interactions necessary for the recombinational repair of DNA strand breaks. Using biochemistry, structural biology and molecular genetics, his lab has determined mechanisms of DNA repair that act to prevent tumourigenesis, in particular focusing on the BRCA2 protein that is defective in inheritable breast and ovarian cancers.

In this lecture, Steve will present cryo-EM studies that define the structure and mechanism of action of the human RAD52 and RAD51 paralog complexes, and will provide new insights into novel therapeutic approaches that aim to kill BRCA-defective cancers.