En direct

Le Centre de Recherche en Cancérologie de Marseille fête ses 50 ans ! -

Salle Bibliothèque CRCM
Séminaires externes
10 Jan 23 11:00 au 10 Jan 23 12:30

Matthias Altmeyer

CRCM and Mauro Modesti are pleased to invite Matthias Altmeyer, Research Group Leader, Department of Molecular Mechanisms of Disease, University of Zurich.

 

“Dynamics and functions of DNA repair compartments”
 

 

Genome stability is constantly challenged by reactive byproducts of cellular metabolism and environmental toxins. Dedicated repair pathways have evolved to deal with DNA damage, and their malfunctioning is associated with human diseases such as cancer and neurodegeneration. Elucidation of the hierarchy and temporal order in which DNA damage-sensing proteins as well as signaling and repair factors assemble around DNA lesions has painted a complex picture of tightly regulated macromolecular interactions that build specialized nuclear compartments to facilitate repair and maintain genome integrity. While many of the underlying interactions, e.g. between repair factors and damage-induced histone modifications, can be explained by lock-and-key or induced fit binding models assuming fixed stoichiometries, structurally less well defined interactions, such as the highly dynamic multivalent interactions implicated in biomolecular condensate formation by phase separation, also participate in the formation of multi-protein assemblies at sites of DNA damage. In this seminar, a summary and an update will be provided on efforts to characterize and better understand the dynamics and functions of cellular DNA repair compartments and how they coordinate maintenance of genome integrity in space and time.

 

Tuesday January 10th, 2023 at 11am

at CRCM Library, 27 boulevard Lei Roure 13009 Marseille

and online https://teams.microsoft.com/l/meetup-join/19%3ameeting_NjFjZGI0ZTctNGRlZC00ZjFkLWEwZDItYjhjZmMyZTEzZGQ1%40thread.v2/0?context=%7b%22Tid%22%3a%2299dde8fb-92f6-414d-bc5e-44ffa3e2419c%22%2c%22Oid%22%3a%22f2f31520-e3bf-470f-8091-b7d9058ffc8b%22%7d