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CRCM - Bibliothèque
Séminaires externes
19 Nov 21 16:00 au 19 Nov 21 17:30

Seminar Lionel Larue

CRCM is pleased to invite Lionel LARUE from Institut Curie, Orsay

 

“The complex relationship between ß–catenin, Mitf, and Brn2 in melanoma”
 

Before establishing his own laboratory, Lionel Larue performed his PhD at Gustave-Roussy in Villejuif (France), in the department of Molecular Pharmacology directed by Claude Paoletti & Jean-Bernard Le Pecq. He performed his post-doctoral training with Beatrice Mintz at the Fox Chase Cancer Center in Philadelphia (USA), on determination, differentiation, and transformation of melanocytes. He moved back to Europe, Freiburg (Germany), where he worked with Rolf Kemler at the Max-Planck Institut für Immunbiologie, where he concentrated his effort on sophisticated, at the time, mouse molecular genetics involving embryonic stem cells and conditional mutations. Lionel Larue focused his attention on pre-implantation and gastrulation, improving his knowledge on the cadherin-catenin complex genes.

Currently, Lionel Larue is research director (INSERM) at Institut Curie, Orsay, France in an INSERM-CNRS department acting as deputy director. For about 25 years, his laboratory focuses on molecular genetics involving the melanocyte lineage. In order to better understand normal and pathological development of melanocytes, the laboratory studies the molecular and cellular mechanisms occurring during the establishment of the melanocyte lineage, homeostasis and transformation. The laboratory aims to improve understanding, in an integrative manner, of the molecular and cellular mechanisms associated with the normal and pathological development of melanocytes and melanoma. Consequently, the laboratory generates crucial information to the understanding of the establishment of melanocytes from melanoblasts during development and the renewal of melanocytes from melanocyte stem cells. This last event is of course important during aging. Moreover, the lab is deciphering, in vitro and in vivo, various signaling pathways, including MAPK, PI3K and WNT. In particular, lab members study proteins engaged in melanoma initiation: BRAF/NRAS, involved in proliferation, and CDKN2A/PTEN/CTNNB1 involved in immortalisation. Generating appropriate models and approaches are essential for advances in understanding melanoma initiation and progression. We are also developing a coherent in vitro and in vivo preclinical pipeline using human and mouse cell lines (2D and 3D) and associated mouse models to effectively test novel cancer therapies.

 

Save the date: Friday, November 19th  4.00pm to 5.30pm

CRCM «bibliothèque» (limited due to sanitary restriction)

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