Ylli Doksani “Two things that can go wrong at telomeres”
Ylli Doksani, PhD IFOM | Principal Investigator | Replication Stress Response Lab
“Two things that can go wrong at telomeres”
Telomere erosion can promote cellular senescence and genome instability, two hallmarks of aging and tumorigenesis. We study the consequences of DNA damage and replication stress on the maintenance of telomeric repeats. By visualizing purified telomeres in electron microscopy, we have identified an unanticipated mechanism by which DNA damage leads to telomere erosion via formation of extrachromosomal circular DNA as well the consequences of replication stress on telomeric forks.
Wednesday December 7th, 2022 at 11am
at CRCM Library (27 boulevard Lei Roure 13009 Marseille)