Cell Communication and Microenvironment (CoMET)

The Cellular Communication and Microenvironment Department (CoMET), led by Dr. Sophie VASSEUR, consists of 5 research teams with the objective of understanding the biological mechanisms influencing the survival, plasticity, dissemination, and resistance of cancer cells to treatments. Their research spans the biology of cancer at the cellular and tumor levels, integrating the microenvironment. The ultimate goal is to identify therapeutic targets and enhance the understanding of tumor biology for clinical application. Their work covers various aspects of cancer, including tumor metabolism, cellular communication, signaling, and drug development.

Collaboration with clinical teams ensures project relevance, particularly for aggressive cancers such as those of the pancreas, breast, liver, and lung. The department also promotes inter-departmental collaboration and the use of patient samples to address mechanisms of tumor progression and treatment resistance.