A continuum in cancer research, from basic research, to translational and clinical research
The Centre de Recherche en Cancérologie de Marseille (CRCM, Cancer Research Center of Marseille) affiliated to Inserm (UMR1068), CNRS (UMR7258) and Aix-Marseille University (UM105) is an original center in the landscape of French research. This originality is not only due to its location in the heart of the Institut Paoli-Calmettes (IPC) but also to his vocation: to advance the biology and medicine of cancer while working at the physiological and pathological interface, the fundamental and the applied, research and the clinic. This continuum between basic research, translational research and clinical research is really the hallmark of the CRCM. As an example, most of our publications are co-authored by scientists and clinicians, which is far from the norm in our discipline.
We explore communication networks (signals, surface receptors, communication nodes…) that regulate the action of cancer cells and immune cells and seek to identify genetic alterations (from point mutations of a gene to complex chromosomal abnormalities) leading to the transformation of a healthy cell into a tumor cell.
This work has already helped improve our understanding of the disease, to better understand how immune cells fight it and the strategies used by tumor cells in an attempt to escape them. They also led to the discovery of new molecular targets that are now the subject of diagnostic and therapeutic applications in oncology.
Director of the CRCM
Deputy director of the CRCM (Luminy site)
Deputy director of the CRCM (IPC site)
The originality of the CRCM lies in its capacity to treat major clinical problems (resistance to treatment, prognosis, anti-metastasis strategies …) thanks to our interactive translational and clinical programs involving physicianss, pharmacists and scientists.
- 400 people (researchers, teacher-researchers, clinicians, post docs, engineers, technicians, administrative staff and students)
- 8000m2 of laboratory area
- 19 research teams working closely with IPC clinical teams
- Their priority scientific and medical activities are, on the one hand, to decipher the molecular bases of oncogenesis and tumor dissemination and, on the other hand, discover and implement therapeutic innovations in the treatment of breast cancer, pancreatic cancer and hematological malignancies.
Nombre de chercheurs au sein de l'institut
17 technological platforms
Scientists and physicians at IPC and at CRCM have access to state-of-the-art technological facilities, covering all experimental models and all scales of analysis, to improve diagnosis, treatment monitoring and the follow up of patients.