PDZome-wide and structural characterization of the PDZ-binding motif of VANGL2.


The Marseille Cancer Research Center celebrates its 50th anniversary ! -

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Dec 2023 Biochimica et biophysica acta. Proteins and proteomics

PDZome-wide and structural characterization of the PDZ-binding motif of VANGL2.

Montserrat-Gomez M, Gogl G, Carrasco K, Betzi S, Durbesson F, Cousido-Siah A, Kostmann C, Essig DJ, Strømgaard K, Østergaard S, Morelli X, Trave G, Vincentelli R, Bailly E, Borg JP

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Dec 2023 Molecular cancer therapeutics

4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.

Calbert ML, Chandramouly G, Adams CM, Saez-Ayala M, Kent T, Tyagi M, Ayyadevara VSSA, Wang Y, Krais JJ, Gordon J, Atkins J, Toma MM, Betzi S, Boghossian AS, Rees MG, Ronan MM, Roth JA, Goldman AR, Gorman N, Mitra R, Childers WE, Graña X, Skorski T, Johnson N, Hurtz C, Morelli X, Eischen CM, Pomerantz RT

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Sep 2023 Proceedings of the National Academy of Sciences of the United States of America

PDZ scaffolds regulate extracellular vesicle production, composition, and uptake.

Castro-Cruz M, Hyka L, Daaboul G, Leblanc R, Meeussen S, Lembo F, Oris A, Van Herck L, Granjeaud S, David G, Zimmermann P

Jul 2023 BMC biology

Population transcriptogenomics highlights impaired metabolism and small population sizes in tree frogs living in the Chernobyl Exclusion Zone.

Car C, Gilles A, Goujon E, Muller MD, Camoin L, Frelon S, Burraco P, Granjeaud S, Baudelet E, Audebert S, Orizaola G, Armengaud J, Tenenhaus A, Garali I, Bonzom JM, Armant O

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Jun 2023 Cancer research

CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer.

Fattori S, Le Roy A, Houacine J, Robert L, Abes R, Gorvel L, Granjeaud S, Rouvière MS, Ben Amara A, Boucherit N, Tarpin C, Pakradouni J, Charafe-Jauffret E, Houvenaeghel G, Lambaudie E, Bertucci F, Rochigneux P, Gonçalves A, Foussat A, Chrétien AS, Olive D

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May 2023 Nature communications

From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia.

Saez-Ayala M, Hoffer L, Abel S, Ben Yaala K, Sicard B, Andrieu GP, Latiri M, Davison EK, Ciufolini MA, Brémond P, Rebuffet E, Roche P, Derviaux C, Voisset E, Montersino C, Castellano R, Collette Y, Asnafi V, Betzi S, Dubreuil P, Combes S, Morelli X

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Mar 2023 Matrix biology : journal of the International Society for Matrix Biology

Tonic repression of Collagen I by the Bradykinin receptor 2 in skin fibroblasts.

Wong HH, Seet SH, Bascom CC, Isfort RJ, Bard F

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Mar 2023 Journal of medicinal chemistry

Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach.

Hoffer L, Garcia M, Leblanc R, Feracci M, Betzi S, Ben Yaala K, Daulat AM, Zimmermann P, Roche P, Barral K, Morelli X

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Dec 2022 Clinical cancer research : an official journal of the American Association for Cancer Research

Mass Cytometry Reveals Classical Monocytes, NK Cells, and ICOS+ CD4+ T Cells Associated with Pembrolizumab Efficacy in Patients with Lung Cancer.

Rochigneux P, Lisberg A, Garcia A, Granjeaud S, Madroszyk A, Fattori S, Gonçalves A, Devillier R, Maby P, Salem N, Gorvel L, Chanez B, Gukasyan J, Carroll J, Goldman J, Chretien AS, Olive D, Garon EB

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Oct 2022 The FEBS journal

Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis.

Barelier S, Avellan R, Gnawali GR, Fourquet P, Roig-Zamboni V, Poncin I, Point V, Bourne Y, Audebert S, Camoin L, Spilling CD, Canaan S, Cavalier JF, Sulzenbacher G