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Sep 2015 Oncoimmunology

A novel actor in antitumoral immunity: The thymus-specific serine protease TSSP/PRSS16 involved in CD4 T-cell maturation.

Authors

Brisson L, Carrier A

Summary

The maturation of a specific subset of CD4 T lymphocytes in the thymus is dependent on cortical thymic epithelial cells expressing the protease thymus-specific serine protease (TSSP, also known as PRSS16). Recently, we unveiled the involvement of TSSP in tumor suppression through its effect on the CD4 T compartment.

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