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Oct 2007 Arthritis and rheumatism

Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis.

Authors

Parel Y, Aurrand-Lions M, Scheja A, Dayer JM, Roosnek E, Chizzolini C

Summary

Fibrotic skin changes in systemic sclerosis (SSc) are preceded by the appearance of an inflammatory infiltrate rich in T cells. Since no direct comparison with T cells in normal skin has been performed previously, this study was undertaken to functionally characterize T cells in the skin of patients with early active SSc and in normal skin.

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