The Marseille Cancer Research Center celebrates its 50th anniversary ! -
TrGET is a preclinical testing platform, specialized in the implementation and development of in vitro and in vivo tests to evaluate the involvement of a target gene in tumorigenesis or the biological activity of anti-tumor compounds with therapeutic potential. Significant efforts are being made in technological development aspects (development of tests, tools and proposed cellular and animal models).
Applications
The platform offers a variety of flexible and adaptable tests, based mainly on bioluminescence technology.
In vitro (96-well format):
proliferation/cytotoxicity / survival-apoptosis / clonogenicity / migration / angiogenesis /
In vivo (non-invasive intravital imaging):
tumor volume / progression or doubling time / tumor spread (blood, marrow, spleen,…) and metastasis / survival
tissue sampling, preparation and storage
Lipskaia L, Breau M, Cayrou C, Churikov D, Braud L, Jacquet J, Born E, Fouillade C, Curras-Alonso S, Bauwens S, Jourquin F, Fiore F, Castellano R, Josselin E, Sánchez-Ferrer C, Giovinazzo G, Lachaud C, Gilson E, Flores I, Londono-Vallejo A, Adnot S, Géli V
Leblanc R, Ghossoub R, Goubard A, Castellano R, Fares J, Camoin L, Audebert S, Balzano M, Bou-Tayeh B, Fauriat C, Vey N, Garciaz S, Borg JP, Collette Y, Aurrand-Lions M, David G, Zimmermann P
Saez-Ayala M, Hoffer L, Abel S, Ben Yaala K, Sicard B, Andrieu GP, Latiri M, Davison EK, Ciufolini MA, Brémond P, Rebuffet E, Roche P, Derviaux C, Voisset E, Montersino C, Castellano R, Collette Y, Asnafi V, Betzi S, Dubreuil P, Combes S, Morelli X
