The crcm's missions

crcm missions

A pioneer in cancer research, the Cancer Research Center of Marseille (CRCM) has been working for over 50 years to better understand the major biological mechanisms behind the disease and translate them into medical innovations. The CRCM stands out for its integrative approach - combining fundamental, translational and clinical research - in close collaboration with the Paoli-Calmettes Institute, the regional cancer center. This synergy, which brings laboratory research closer to clinical applications, makes CRCM a major player in the understanding and treatment of cancer.

the crcm's 4 research areas

the crcm's 4 lines of research

Cell communication &
Microenvironment dpt.

Genome integrity dpt.

Onco-hematology &
Immuno-oncology dpt.

Translational research &
Innovative therapies dpt.

The news

2 June 2026
CDK1 phosphorylation switches SLX4 SAP from DNA binding to MUS81 binding
Scaglione and Gaillard show that the SLX4 SAP domain selectively binds four-way branched DNA structures. Their findings identify CDK1 phosphorylation as a molecular switch that inhibits DNA binding while promoting MUS81 interaction, thereby temporally controlling distinct SAP functions.

The events

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Events

Today

crcm and ipc

Working closely together to advance
cancer research.

crcm and ipc

Working closely together to advance
cancer research.

Logo Aix Marseille université CRCM partenaires Logo Inserm partenaire CRCM Institut Paoli Calmettes unicancer Marseille CRCM