A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity.
Auteurs
Xia Y, Wang M, Demaria O, Tang J, Rocchi P, Qu F, Iovanna JL, Alexopoulou L, Peng L
Résumé
A novel bitriazolyl acyclonucleoside was discovered to exhibit powerful antiproliferative effects on different cancer cell lines through caspase-dependent apoptosis and at the same time stimulate the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling. This promising compound with dual anticancer and immunomodulatory activity may represent a new generation of highly efficacious drug candidates for use in cancer therapy.
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