Jan 2016 Molecular & cellular oncology

A phenotypic and mechanistic perspective on heterogeneity of HER2-positive breast cancers.

Auteurs

Ferrari A, Sertier AS, Vincent-Salomon A, Pivot X, Pauporté I, Saintigny P, Birnbaum D, Viari A

Résumé

Analysis of gene expression and whole-genome features of 64 human epidermal growth factor 2 ()-positive breast tumors supports the idea that their intrinsic heterogeneity actually reflects their cell of origin, suggesting that amplification is an embedded event in the natural history of these tumors. Possible mechanisms for this event involve breakage-fusion-bridge and chromothripsis.

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