Feb 2012 Chemistry (Weinheim an der Bergstrasse, Germany)

An efficient mixed-ligand Pd catalytic system to promote C-N coupling for the synthesis of N-arylaminotriazole nucleosides.

Auteurs

Fan Y, Xia Y, Tang J, Ziarelli F, Qu F, Rocchi P, Iovanna JL, Peng L

Résumé

Make it unique! A mixed-ligand system of Pd/Synphos/Xantphos promotes effective C-N coupling in the synthesis of various N-arylaminotriazole and N-arylaminopurine nucleoside analogues. This catalytic system is strikingly powerful and efficient, allowing for unparalleled substrate scope and high product yields as well as promotion of C-Cl bond activation for C-N coupling (see scheme).

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