Nov 2012 BMC genomics

Anopheles salivary gland proteomes from major malaria vectors.

Auteurs

Fontaine A, Fusaï T, Briolant S, Buffet S, Villard C, Baudelet E, Pophillat M, Granjeaud S, Rogier C, Almeras L

Résumé

Antibody responses against Anopheles salivary proteins can indicate individual exposure to bites of malaria vectors. The extent to which these salivary proteins are species-specific is not entirely resolved. Thus, a better knowledge of the diversity among salivary protein repertoires from various malaria vector species is necessary to select relevant genus-, subgenus- and/or species-specific salivary antigens. Such antigens could be used for quantitative (mosquito density) and qualitative (mosquito species) immunological evaluation of malaria vectors/host contact. In this study, salivary gland protein repertoires (sialomes) from several Anopheles species were compared using in silico analysis and proteomics. The antigenic diversity of salivary gland proteins among different Anopheles species was also examined.

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