Jan 2009 Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Autophagy and VMP1 expression are early cellular events in experimental diabetes.

Auteurs

Grasso D, Sacchetti ML, Bruno L, Lo Ré A, Iovanna JL, Gonzalez CD, Vaccaro MI

Résumé

We have described VMP1 as a new protein which expression triggers autophagy in mammalian cells. Here we show that experimental diabetes activates VMP1 expression and autophagy in pancreas beta cells as a direct response to streptozotocin (STZ).

Lire l‘article