May 2006 BMC genomics

Direct and heterologous approaches to identify the LET-756/FGF interactome.

Auteurs

Popovici C, Berda Y, Conchonaud F, Harbis A, Birnbaum D, Roubin R

Résumé

Fibroblast growth factors (FGFs) are multifunctional proteins that play important roles in cell communication, proliferation and differentiation. However, many aspects of their activities are not well defined. LET-756, one of the two C. elegans FGFs, is expressed throughout development and is essential for worm development. It is both expressed in the nucleus and secreted.

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