En direct

Géraldine Guasch (CRCM) - Publication dans Nature Communications -

Aug 2019 Chemical communications (Cambridge, England)

Flavonoid-alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation.

Auteurs

Zhou Z, Luo B, Liu X, Chen M, Lan W, Iovanna JL, Peng L, Xia Y

Résumé

Cancer development is often associated with lipid metabolic reprogramming, including aberrant lipid accumulation. We create novel paradigms endowed with dual functions of anticancer activity and inhibition of lipid accumulation by conjugating the natural product quercetin and synthetic alkylphospholipid drugs, and harnessing the biomedical effects of both. These conjugates offer fresh perspectives in the search for anticancer candidates.

Lire l‘article