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Jan 2017 Molecular & cellular oncology

Flick the cancer stem cells’ switch to turn cancer off.

Résumé

Tumors are organized in a cellular hierarchy with a population of cancer stem cell (CSC) driving cancer progression and resistance to treatment. Recently, we identified miR-600 as a bimodal switcher that balances breast CSC-fate from a self-renewing to a differentiation state, with a direct impact on tumor progression.

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