Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis.
Auteurs
Cano CE, Hamidi T, Garcia MN, Grasso D, Loncle C, Calvo E, Lomberk G, Dusetti N, Bartholin L, Urrutia R, Iovanna JL
Résumé
Nuclear protein 1 (Nupr1) is a major factor in the cell stress response required for Kras(G12D)-driven formation of pancreatic intraepithelial neoplastic lesions (PanINs). We evaluated the relevance of Nupr1 in the development of pancreatic cancer.
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