Getting to the root of BRCA1-deficient breast cancer.
Ginestier C, Wicha MS
Loss of BRCA1 has been shown to expand breast stem cells. In Nature Medicine, Lim et al. (2009) demonstrate that breast tissue from BRCA1 mutation carriers contains expanded luminal progenitor cells, suggesting a broader role for BRCA1 in mammary development.Lire l‘article