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Mar 2015 Pathogens and disease

Imbalance of circulating lymphoid cells in Q fever endocarditis.


Ka MB, Gondois-Rey F, Ghigo E, Raoult D, Olive D, Mege JL


Q fever endocarditis is characterized by a defective cell-mediated immune response, which may be associated with the dysregulation of circulating subsets of immune cells. In this study, we found that naïve CD8(+) T lymphocytes and CD56dim natural killer cells were decreased patients whereas central memory CD8(+) T lymphocytes were increased. It is likely that these different subsets of immune cells play a role in the immunosuppression accompanying Q fever endocarditis.

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