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Oct 2009 The Journal of antimicrobial chemotherapy

In vitro antibacterial activity of aminosterols against multidrug-resistant bacteria from patients with cystic fibrosis.


Alhanout K, Raoult D, Rolain JM


Respiratory infections with multidrug-resistant (MDR) bacteria are life-threatening in patients with cystic fibrosis (CF). Squalamine and aminosterol derivatives (ASDs) have previously demonstrated interesting antibacterial activity against bacterial reference strains. This study investigated for the first time their activity against MDR clinical isolates recovered from the sputa of CF patients.

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