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Jan 2012 Oncoimmunology

Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer.

Auteurs

Béraud E, Collignon A, Franceschi C, Olive D, Lombardo D, Mas E

Résumé

Glycoproteins, as valuable targets for dendritic cell (DC)-vaccination in cancers, remain an open question. Glycosylated structures, which are aberrantly modified during cancerisation, impact positively or negatively on glycoprotein immunogenicity. Here is presented an oncofetal glycovariant of bile-salt-dependent-lipase, expressed on human tumoral pancreas and efficiently processed by DC’s, inducing T-lymphocyte activation.

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