Aug 2009 Arteriosclerosis, thrombosis, and vascular biology

JAM-C induces endothelial cell permeability through its association and regulation of {beta}3 integrins.


Li X, Stankovic M, Aurrand-Lions M, Hahn CN, Lu Y, Imhof BA, Vadas MA, Gamble JR


The molecular mechanisms regulating vascular permeability are only now being elucidated. The junctional adhesion molecule (JAM) JAM-C has been linked to the induction of vascular permeability. We sought to understand the mechanism whereby JAM-C may disrupt junctional integrity in endothelial cells (ECs).

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