Jan 2014 Brain, behavior, and immunity

Leukocyte telomere length in mastocytosis: correlations with depression and perceived stress.

Auteurs

Georgin-Lavialle S, Moura DS, Bruneau J, Chauvet-Gélinier JC, Damaj G, Soucie E, Barete S, Gacon AL, Grandpeix-Guyodo C, Suarez F, Launay JM, Durieu I, Esparcieux A, Guichard I, Sparsa A, Nicolini F, Gennes Cd, Trojak B, Haffen E, Vandel P, Lortholary O, Dubreuil P, Bonin B, Sultan S, Teyssier JR, Hermine O

Résumé

Mastocytosisis a rare disease associated with chronic symptoms related to mast cell mediator release. Patients with mastocytosis display high level of negative emotionality such as depression and stress sensibility. Brain mast cells are mainly localized in the diencephalon, which is linked to emotion regulatory systems. Negative emotionality has been shown to be associated with telomere shortening. Taken together these observations led us to hypothesize that mast cells activity could be involved in both negative emotionality and telomere shortening in mastocytosis.

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