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Jan 2017 Stem cells international

Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1.

Auteurs

Rowart P, Erpicum P, Krzesinski JM, Sebbagh M, Jouret F

Résumé

Mesenchymal stromal cells (MSC) are fibroblast-like multipotent cells capable of tissue-repair properties. Given the essentiality of tight junctions (TJ) in epithelial integrity, we hypothesized that MSC modulate TJ formation, via the AMP-activated kinase (AMPK) pathway. Liver kinase-1 (LKB1) and Ca-calmodulin-dependent protein kinase kinase (CaMKK) represent the main kinases that activate AMPK.

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