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Géraldine Guasch (CRCM) - Publication dans Nature Communications -

Mar 2015 Clinical cancer research : an official journal of the American Association for Cancer Research

Pathological response and circulating tumor cell count identifies treated HER2+ inflammatory breast cancer patients with excellent prognosis: BEVERLY-2 survival data.

Auteurs

Pierga JY, Petit T, Lévy C, Ferrero JM, Campone M, Gligorov J, Lerebours F, Bachelot T, Charafe-Jauffret E, Bonneterre J, Bidard FC, Viens P

Résumé

The BEVERLY-2 single-arm phase II trial assessed the efficacy and safety of combining neoadjuvant chemotherapy with bevacizumab and trastuzumab for the treatment of HER2-positive inflammatory breast cancer (IBC). Here, we report the results of a preplanned survival analysis at 3 years of follow-up, along with the association between outcome and circulating biomarkers and pathologic complete response (pCR).

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