06 2016 Future medicinal chemistry

Polyamine derivatives: a revival of an old neglected scaffold to fight resistant Gram-negative bacteria?

Auteurs

Blanchet M, Borselli D

Résumé

Emergence of multidrug-resistant pathogens was responsible for microbial infections and inefficacy of numerous antimicrobial therapies has induced a need for the research of new classes of antibiotics. In this review, we will focus our interest toward the biological properties of polyamino antimicrobial agents.

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