Jul 2013 Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Prognostic score including gene mutations in chronic myelomonocytic leukemia.

Auteurs

Itzykson R, Kosmider O, Renneville A, Gelsi-Boyer V, Meggendorfer M, Morabito M, Berthon C, Adès L, Fenaux P, Beyne-Rauzy O, Vey N, Braun T, Haferlach T, Dreyfus F, Cross NC, Preudhomme C, Fontenay M, Vainchenker W, Schnittger S, Birnbaum D, Droin N, Solary E

Résumé

Several prognostic scoring systems have been proposed for chronic myelomonocytic leukemia (CMML), a disease in which some gene mutations-including ASXL1-have been associated with poor prognosis in univariable analyses. We developed and validated a prognostic score for overall survival (OS) based on mutational status and standard clinical variables.

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