May 2014 BMC molecular biology

Single and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks.

Auteurs

Calvo E, Grzenda A, Lomberk G, Mathison A, Iovanna J, Urrutia R

Résumé

Krüppel-like factors (KLFs) are a group of master regulators of gene expression conserved from flies to human. However, scant information is available on either the mechanisms or functional impact of the coupling of KLF proteins to chromatin remodeling machines, a deterministic step in transcriptional regulation.

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