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Le Centre de Recherche en Cancérologie de Marseille fête ses 50 ans ! -

Aug 2016 Current genetics

Single-strand gap repair involves both RecF and RecBCD pathways.


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Homologous recombination repairs discontinuities in DNA including single-strand gaps (SSGs) and double-strand breaks (DSBs). This commentary describes how the RecBCD and RecF pathways might be exchangeable for the repair of their respective DSB and SSG canonical substrates. In particular, I will discuss how the RecBCD pathway could engage in the repair of an SSG even when the latter is not associated with a DSB.

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