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Jun 2011 The Journal of antimicrobial chemotherapy

Squalamine ointment for Staphylococcus aureus skin decolonization in a mouse model.


Djouhri-Bouktab L, Alhanout K, Andrieu V, Raoult D, Rolain JM


Staphylococcus aureus colonization of the skin and the nostrils remains a major cause of surgical-site infections despite preoperative and preventive procedures. To date, many compounds have been used for S. aureus decolonization, including mupirocin ointments and antiseptics, with variable results. The emergence of mupirocin-resistant S. aureus strains has led to the search for new antimicrobial agents specifically for S. aureus decolonization. In this work we evaluated squalamine and related parent-derived ointments (1%) as potential new compounds for S. aureus decolonization in a new mouse model.

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