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Géraldine Guasch (CRCM) - Publication dans Nature Communications -

Jul 2017 Organic & biomolecular chemistry

Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A.


Fong HKH, Longeon A, Bourguet-Kondracki ML, Barker D, Copp BR


Synthesis of the antimicrobial marine natural product halocyamine A has been achieved utilizing a combination of Sonogashira coupling, ruthenium complex/ytterbium triflate catalyzed hydroamidation and solid-phase peptide synthesis (SPPS) chemistry. The synthetic natural product exhibited only modest levels of antibacterial activities but significant antioxidant activity.

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