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Jan 2015 Advances in protein chemistry and structural biology

The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer.


Karaki S, Andrieu C, Ziouziou H, Rocchi P


Cancer cells depend on cap-dependent translation more than normal tissue. This explains the emergence of proteins involved in the cap-dependent translation as targets for potential anticancer drugs. Cap-dependent translation starts when eIF4E binds to mRNA cap domain. This review will present eIF4E’s structure and functions. It will also expose the use of eIF4E as a therapeutic target in cancer.

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