Dec 2010 BMC biochemistry

The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac.

Auteurs

Fei F, Kweon SM, Haataja L, De Sepulveda P, Groffen J, Heisterkamp N

Résumé

RhoGDI proteins are important regulators of the small GTPase Rac, because they shuttle Rac from the cytoplasm to membranes and also protect Rac from activation, deactivation and degradation. How the binding and release of Rac from RhoGDI is regulated is not precisely understood.

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