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Les mitochondries nouvelles cibles thérapeutiques potentielles dans le cancer du pancréas -

Mar 2016 Oncoimmunology

The PD1/PDL1 axis, a promising therapeutic target in aggressive breast cancers.

Résumé

Analysis of mRNA expression in ∼5,500 breast cancers showed upregulation in 38% of basal tumors and 38% of inflammatory breast cancers (IBC). Upregulation, associated with signs of strong cytotoxic local immune response, was associated with a better survival in the basal or triple-negative subtypes, and with a better pathological response to chemotherapy in these subtypes and IBC. Reactivation of dormant tumor-infiltrating lymphocytes (TILs) by PD1/PDL1-inhibitors represents a promising strategy in these aggressive tumors.

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