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Jun 2008 PloS one

The WSB1 gene is involved in pancreatic cancer progression.


Archange C, Nowak J, Moutardier V, Calvo EL, Dagorn JC, Iovanna JL


Pancreatic cancer cells generate metastases because they can survive the stress imposed by the new environment of the host tissue. To mimic this process, pancreatic cancer cells which are not stressed in standard culture conditions are injected into nude mice. Because they develop xenografts, they should have developed adequate stress response. Characterizing that response might provide new strategies to interfere with pancreatic cancer metastasis.

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