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Le Centre de Recherche en Cancérologie de Marseille fête ses 50 ans ! -

Apr Feb 2006 Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Microtubule-targeting agents in angiogenesis: where do we stand?


Pasquier E, Honoré S, Braguer D


Angiogenesis is a key event of tumor progression and metastasis and hence a target for cancer chemotherapy. Therapeutic strategies focused on angiogenesis include the discovery of new, targeted anti-angiogenic agents and the re-evaluation of conventional anti-cancer drugs. Here, we review the most recent studies investigating the molecular and cellular mechanisms responsible for the anti-angiogenic activity of microtubule-targeting agents (MTAs). These agents include some of the most widely used and effective antitumor drugs that are also among the most anti-angiogenic. In addition, we summarize the latest results of pre-clinical and clinical studies involving MTAs administered at low metronomic doses and in anti-angiogenic combination strategies. Finally, we discuss the future development of these agents, their clinical potential and their limitations.

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