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Les mitochondries nouvelles cibles thérapeutiques potentielles dans le cancer du pancréas -

Mar 2010 PloS one

Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database.


Bourgeas R, Basse MJ, Morelli X, Roche P


In the last decade, the inhibition of protein-protein interactions (PPIs) has emerged from both academic and private research as a new way to modulate the activity of proteins. Inhibitors of these original interactions are certainly the next generation of highly innovative drugs that will reach the market in the next decade. However, in silico design of such compounds still remains challenging.

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