Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions.
Bosc N, Muller C, Hoffer L, Lagorce D, Bourg S, Derviaux C, Gourdel ME, Rain JC, Miller TW, Villoutreix BO, Miteva MA, Bonnet P, Morelli X, Sperandio O, Roche P
Philippe Roche
Publications
CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy.
Hoffer L, Saez-Ayala M, Horvath D, Varnek A, Morelli X, Roche P
Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.
Hoffer L, Voitovich YV, Raux B, Carrasco K, Muller C, Fedorov AY, Derviaux C, Amouric A, Betzi S, Horvath D, Varnek A, Collette Y, Combes S, Roche P, Morelli X
Modulation of Re-initiation of Measles Virus Transcription at Intergenic Regions by PXD to NTAIL Binding Strength.
Bloyet LM, Brunel J, Dosnon M, Hamon V, Erales J, Gruet A, Lazert C, Bignon C, Roche P, Longhi S, Gerlier D
2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions.
Basse MJ, Betzi S, Morelli X, Roche P
Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I).
Morelli X, Bourgeas R, Roche P
A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays.
Guiseppi A, Vicente JJ, Herrou J, Byrne D, Barneoud A, Moine A, Espinosa L, Basse MJ, Molle V, Mignot T, Roche P, Mauriello EMF
From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia.
Saez-Ayala M, Hoffer L, Abel S, Ben Yaala K, Sicard B, Andrieu GP, Latiri M, Davison EK, Ciufolini MA, Brémond P, Rebuffet E, Roche P, Derviaux C, Voisset E, Montersino C, Castellano R, Collette Y, Asnafi V, Betzi S, Dubreuil P, Combes S, Morelli X