iSCB Team 2020
iSCB Team 2020

Xavier Morelli

Responsable d'équipe Directeur de Recherche CNRS (DR2)
Publications
May 2020 ACS chemical biology

Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions.

Bosc N, Muller C, Hoffer L, Lagorce D, Bourg S, Derviaux C, Gourdel ME, Rain JC, Miller TW, Villoutreix BO, Miteva MA, Bonnet P, Morelli X, Sperandio O, Roche P

Oct 2020 Molecular oncology

In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor.

Ariey-Bonnet J, Carrasco K, Le Grand M, Hoffer L, Betzi S, Feracci M, Tsvetkov P, Devred F, Collette Y, Morelli X, Ballester P, Pasquier E

Apr 2019 Journal of chemical information and modeling

CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy.

Hoffer L, Saez-Ayala M, Horvath D, Varnek A, Morelli X, Roche P

Aug 2021 mBio

Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex.

Cherrak Y, Filella-Merce I, Schmidt V, Byrne D, Sgoluppi V, Chaiaheloudjou R, Betzi S, Morelli X, Nilges M, Pellarin R, Durand E

Feb 2021 Biology of the cell

The NANOTUMOR consortium – Towards the Tumor Cell Atlas.

Colin F, Schauer K, Hamiche A, Martineau P, Borg JP, Bednar J, Bertolin G, Camoin L, Collette Y, Dimitrov S, Fournier I, Hyenne V, Mendoza-Parra MA, Morelli X, Rondé P, Sumara I, Tramier M, Schultz P, Goetz JG

Dec 2020 Journal of extracellular vesicles

Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo.

Leblanc R, Kashyap R, Barral K, Egea-Jimenez AL, Kovalskyy D, Feracci M, Garcia M, Derviaux C, Betzi S, Ghossoub R, Platonov M, Roche P, Morelli X, Hoffer L, Zimmermann P

Jan 2019 European journal of medicinal chemistry

Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors.

Hernandez J, Hoffer L, Coutard B, Querat G, Roche P, Morelli X, Decroly E, Barral K

Sep 2018 Molecular informatics

Chemistry-driven Hit-to-lead Optimization Guided by Structure-based Approaches.

Hoffer L, Muller C, Roche P, Morelli X

Jul 2018 Journal of medicinal chemistry

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.

Hoffer L, Voitovich YV, Raux B, Carrasco K, Muller C, Fedorov AY, Derviaux C, Amouric A, Betzi S, Horvath D, Varnek A, Collette Y, Combes S, Roche P, Morelli X

Nov 2017 Nature communications

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.

Hammam K, Saez-Ayala M, Rebuffet E, Gros L, Lopez S, Hajem B, Humbert M, Baudelet E, Audebert S, Betzi S, Lugari A, Combes S, Letard S, Casteran N, Mansfield C, Moussy A, De Sepulveda P, Morelli X, Dubreuil P

Jun 2017 PLoS genetics

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.

Cartier-Michaud A, Bailly AL, Betzi S, Shi X, Lissitzky JC, Zarubica A, Sergé A, Roche P, Lugari A, Hamon V, Bardin F, Derviaux C, Lembo F, Audebert S, Marchetto S, Durand B, Borg JP, Shi N, Morelli X, Aurrand-Lions M

Feb 2017 The Journal of biological chemistry

Structural Basis for the Interaction between Golgi Reassembly-stacking Protein GRASP55 and Golgin45.

Zhao J, Li B, Huang X, Morelli X, Shi N

Aug 2016 ACS chemical biology

Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery.

Milhas S, Raux B, Betzi S, Derviaux C, Roche P, Restouin A, Basse MJ, Rebuffet E, Lugari A, Badol M, Kashyap R, Lissitzky JC, Eydoux C, Hamon V, Gourdel ME, Combes S, Zimmermann P, Aurrand-Lions M, Roux T, Rogers C, Müller S, Knapp S, Trinquet E, Collette Y, Guillemot JC, Morelli X