iSCB Team 2020
iSCB Team 2020

Xavier Morelli

Responsable d'équipe Directeur de Recherche CNRS (DR2)
May 2020 ACS chemical biology

Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions.

Bosc N, Muller C, Hoffer L, Lagorce D, Bourg S, Derviaux C, Gourdel ME, Rain JC, Miller TW, Villoutreix BO, Miteva MA, Bonnet P, Morelli X, Sperandio O, Roche P

Oct 2020 Molecular oncology

In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor.

Ariey-Bonnet J, Carrasco K, Le Grand M, Hoffer L, Betzi S, Feracci M, Tsvetkov P, Devred F, Collette Y, Morelli X, Ballester P, Pasquier E

Apr 2019 Journal of chemical information and modeling

CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy.

Hoffer L, Saez-Ayala M, Horvath D, Varnek A, Morelli X, Roche P

Jan 2019 European journal of medicinal chemistry

Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors.

Hernandez J, Hoffer L, Coutard B, Querat G, Roche P, Morelli X, Decroly E, Barral K

Sep 2018 Molecular informatics

Chemistry-driven Hit-to-lead Optimization Guided by Structure-based Approaches.

Hoffer L, Muller C, Roche P, Morelli X

Jul 2018 Journal of medicinal chemistry

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.

Hoffer L, Voitovich YV, Raux B, Carrasco K, Muller C, Fedorov AY, Derviaux C, Amouric A, Betzi S, Horvath D, Varnek A, Collette Y, Combes S, Roche P, Morelli X

Nov 2017 Nature communications

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.

Hammam K, Saez-Ayala M, Rebuffet E, Gros L, Lopez S, Hajem B, Humbert M, Baudelet E, Audebert S, Betzi S, Lugari A, Combes S, Letard S, Casteran N, Mansfield C, Moussy A, De Sepulveda P, Morelli X, Dubreuil P

Jun 2017 PLoS genetics

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.

Cartier-Michaud A, Bailly AL, Betzi S, Shi X, Lissitzky JC, Zarubica A, Sergé A, Roche P, Lugari A, Hamon V, Bardin F, Derviaux C, Lembo F, Audebert S, Marchetto S, Durand B, Borg JP, Shi N, Morelli X, Aurrand-Lions M

Feb 2017 The Journal of biological chemistry

Structural Basis for the Interaction between Golgi Reassembly-stacking Protein GRASP55 and Golgin45.

Zhao J, Li B, Huang X, Morelli X, Shi N

Aug 2016 ACS chemical biology

Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery.

Milhas S, Raux B, Betzi S, Derviaux C, Roche P, Restouin A, Basse MJ, Rebuffet E, Lugari A, Badol M, Kashyap R, Lissitzky JC, Eydoux C, Hamon V, Gourdel ME, Combes S, Zimmermann P, Aurrand-Lions M, Roux T, Rogers C, Müller S, Knapp S, Trinquet E, Collette Y, Guillemot JC, Morelli X

Feb 2016 Journal of medicinal chemistry

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.

Raux B, Voitovich Y, Derviaux C, Lugari A, Rebuffet E, Milhas S, Priet S, Roux T, Trinquet E, Guillemot JC, Knapp S, Brunel JM, Fedorov AY, Collette Y, Roche P, Betzi S, Combes S, Morelli X

Jan 2016 Database : the journal of biological databases and curation

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions.

Basse MJ, Betzi S, Morelli X, Roche P

Oct 2015 Progress in biophysics and molecular biology

Editorial. Protein-Protein Interaction Analysis and Modulation.

Ochsenbein F, Morelli X, Verma C