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Les mitochondries nouvelles cibles thérapeutiques potentielles dans le cancer du pancréas -

Aug 2006 Bioorganic & medicinal chemistry

Caulerpenyne-colchicine hybrid: synthesis and biological evaluation.

Auteurs

Bourdron J, Commeiras L, Barbier P, Bourgarel-Rey V, Pasquier E, Vanthuyne N, Hubaud JC, Peyrot V, Parrain JL

Résumé

The synthesis of an analog of caulerpenyne having a trimethoxyaryl moiety was achieved in 11% overall yield over 11 steps. Its biological activity has been evaluated as inhibitor of in vitro tubulin polymerization or angiogenesis.

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